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Nel fu individuata una seconda piccola molecola di RNA codificata dal gene lin-7 con azione repressiva sull'mRNA del gene lin I miRNA con sequenze quasi identiche ad eccezione di uno o due nucleotidi sono annotati con un ulteriore lettera minuscola.

I miRNA derivano da trascritti di sequenze codificate da geni autonomi oppure inclusi in introni di altri geni.

Il trascritto subisce poi un processo di capping al 5', di poliadenilazione al 3' e di splicing. Tali molecole possono derivare dallo splicing diretto degli introni, in maniera indipendente dal complesso microprocessore e prendono il nome di Mirtrons.

Tali molecole furono osservate per la prima volta in Drosophila e C. Al termine del processamento nucleare i pre-miRNA sono esportati nel citoplasma in un processo che coinvolge il trasportatore nucleo-citoplasmatico Esportina-5, il quale riconosce i due nucleotidi sporgenti al 3' lasciati dall'enzima Drosha.

Il taglio genera molecole di RNA a doppio filamento lunghe circa 22 basi. Le proteine Ago possono utilizzare o trattenere i miRNA con molti bersagli e mantenere quelli con pochi o nessun bersaglio.

In particolare sono stati identificati miRNA contenenti residui di uracile e miRNA contenenti gruppi metilici legati al 2' ossidrile.

La presenza di residui di uracile potrebbe rappresentare un segnale che promuove la degradazione, mentre la metilazione impedirebbe l'aggiunta di uracile e quindi avrebbe un effetto protettivo nei confronti della degradazione.

Tali interazioni forniscono al miRNA l'orientazione corretta ai fini dell'interazione con la molecola di mRNA bersaglio.

Alcune Argonauta, come la proteina umana Ago2, possono tagliare il trascritto bersaglio direttamente. I miRNA risultano essere evolutivamente molto conservati e si pensa siano elementi molto antichi dei meccanismi di regolazione dell'espressione genica.

Le molecole costituenti i loro sistemi di espressione risultano essere simili nelle piante e negli animali, ma vi sono delle differenze inerenti ai loro meccanismi di espressione.

I miRNA regolano l'espressione genica secondo meccanismi diversi nelle piante e negli animali.

Keep scrolling for more More Definitions for minor minor. Entry 1 of 2 : not very important or valuable : small in number, quantity, or extent : not very serious : not causing much trouble or damage minor.

Entry 1 of 2 1 : not great in size, importance, or seriousness minor details a minor injury 2 : of or relating to a musical scale having the third tone lowered a half step minor.

Entry 1 of 2 : not serious or involving risk to life minor illness a minor operation — compare major minor.

Entry 1 of 2 : a person who has not yet reached the age of majority — compare adult , juvenile , major minor. Please tell us where you read or heard it including the quote, if possible.

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Phrases Related to minor minor in minor leaguer minor miracle the minors. More Definitions for minor. US : a second subject studied by a college or university student in addition to a main subject.

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